Molecular Formula | C26H29NO2 |
Molar Mass | 387.51 |
Density | 1.092 |
Melting Point | 135-144°C |
Boling Point | 514.4±50.0 °C(Predicted) |
Solubility | methanol: soluble10mg/mL |
Appearance | solution |
Color | white to off-white |
pKa | 9.38±0.15(Predicted) |
Storage Condition | 2-8°C |
Physical and Chemical Properties | Bioactive 4-Hydroxytamoxifen (Afimoxifene) is an active metabolite of tamoxifen and a selective estrogen receptor regulatory molecule, which is widely used in the treatment and chemotherapy of breast cancer. 4-HT activates targeted modification efficiency of intein-Cas9 mutants. |
Use | Uses Afoxifene is the active metabolite of tamoxifen in the body, which can be used as an organic intermediate. |
Hazard Symbols | Xn - Harmful |
Risk Codes | R63 - Possible risk of harm to the unborn child R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. |
Safety Description | S22 - Do not breathe dust. S23 - Do not breathe vapour. S36 - Wear suitable protective clothing. |
UN IDs | UN1170 - class 3 - PG 2 - Ethanol, solution |
WGK Germany | 3 |
RTECS | SL1210000 |
Target
Estrogen receptor
in vitro studies
4-OHT is an effective ER activator. Compared with tamoxifen, it has a higher affinity for estrogen receptors. 4-OHT has a strong dose and time-dependent effect, which can change the contractile function of isolated rat cardiomyocytes. 4-HT activates targeted modification efficiency of intein-Cas9 mutants.