4-Hydroxytamoxifen, (Z)-isomer
(E/Z)-4-Hydroxy Tamoxifen
CAS: 68392-35-8
Molecular Formula: C26H29NO2
4-Hydroxytamoxifen, (Z)-isomer - Names and Identifiers
4-Hydroxytamoxifen, (Z)-isomer - Physico-chemical Properties
| Molecular Formula | C26H29NO2 |
| Molar Mass | 387.51 |
| Density | 1.092 |
| Melting Point | 135-144°C |
| Boling Point | 514.4±50.0 °C(Predicted) |
| Solubility | methanol: soluble10mg/mL |
| Appearance | solution |
| Color | white to off-white |
| pKa | 9.38±0.15(Predicted) |
| Storage Condition | 2-8°C |
| Physical and Chemical Properties | Bioactive 4-Hydroxytamoxifen (Afimoxifene) is an active metabolite of tamoxifen and a selective estrogen receptor regulatory molecule, which is widely used in the treatment and chemotherapy of breast cancer. 4-HT activates targeted modification efficiency of intein-Cas9 mutants. |
| Use | Uses Afoxifene is the active metabolite of tamoxifen in the body, which can be used as an organic intermediate. |
4-Hydroxytamoxifen, (Z)-isomer - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | R63 - Possible risk of harm to the unborn child R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. |
| Safety Description | S22 - Do not breathe dust. S23 - Do not breathe vapour. S36 - Wear suitable protective clothing. |
| UN IDs | UN1170 - class 3 - PG 2 - Ethanol, solution |
| WGK Germany | 3 |
| RTECS | SL1210000 |
4-Hydroxytamoxifen, (Z)-isomer - Upstream Downstream Industry
4-Hydroxytamoxifen, (Z)-isomer - Uses and synthesis methods
Target
Estrogen receptor
in vitro studies
4-OHT is an effective ER activator. Compared with tamoxifen, it has a higher affinity for estrogen receptors. 4-OHT has a strong dose and time-dependent effect, which can change the contractile function of isolated rat cardiomyocytes. 4-HT activates targeted modification efficiency of intein-Cas9 mutants.
Last Update：2024-04-10 22:29:15
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Spot supply
Product Name: (E/Z)-4-Hydroxy Tamoxifen Visit Supplier Webpage Request for quotationCAS: 68392-35-8
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
View History
Raw Materials for 4-Hydroxytamoxifen, (Z)-isomer
4-Hydroxyphenyl 4-Methoxyphenyl ketone
4-(1-(4-(2-bromoethoxy)phenyl)-2-phenylbut-1-en-1-yl)phenol(WXC07440)
1,1-bis(4-hydroxyphenyl)-2-phenylbut-1-ene
4,4'-Dihydroxybenzophenone
Dimethylamine
2-Dimethylaminoethyl chloride hydrochloride
4-(1-(4-(2-bromoethoxy)phenyl)-2-phenylbut-1-en-1-yl)phenol(WXC07440)
1,1-bis(4-hydroxyphenyl)-2-phenylbut-1-ene
4,4'-Dihydroxybenzophenone
Dimethylamine
2-Dimethylaminoethyl chloride hydrochloride